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HLA-B

From investigating HLA-antibody interactions in transplantation to antigen-specific CD8+ cytotoxic T cells in disease states

We provide a suite of highly representative, functionally intact HLA-B alleles with broad population coverage known as the most diverse genetic markers used by the body to accept or reject transplants. Learn more about HLA.

BROWSE ALL sHLA-B ALLELES
HLA-A proteins
Popular Products
HLA–B*07:02
Popular high-frequency allele studied in vaccine design and serological testing
HLA–B*08:01
Prevalent B allele in most populations worldwide and assumed biomarker in leukemia
HLA–B*27:05
Associated with increased risk of developing ankylosing spondylitis and arthritis
HLA–B*57:01
Associated with an extreme sensitivity to abacavir among people with HIV infection
HLA–B*44:02
Among the top B alleles found in the human population
HLA–B*35:01
High “B” frequency allele identified within the world population
HLA–B*40:01
Common alleles found in the world population
HLA–B*51:01
Described as one of the strongest protective B alleles toward HIV infection
Available HLA-B alleles
EXPAND HLA-B MAP

HLA-B Allele Map

Download our list of HLA-B alleles to view all available sHLA proteins as well as products in development.

Download HLA-B Alleles

Featured Assays

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General ImmunoAssays

Soluble HLA are extremely well suited as antigens in solid phase immunoassays for the detection and characterization of HLA-specific antibodies. Because of their antigenic integrity, they provide increased accuracy and specificity.
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Bead-based ImmunoAssays

Biotin-labeled sHLA molecules are easily immobilized on any streptavidin-coated bead in immunoassays to measure antibody analytes. Fluorescent imaging is used to measure the amount of captured antibody.
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Cell-Based ImmunoAssays

Biotin-labeled sHLA proteins coupled with a fluorescently labeled streptavidin conjugate are very sensitive detectors in ELISpot assays to profile the antibody specificities of i.e. HLA-specific B cells.
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Flow Cytometry/Cell Sorting

Immune cells stained with a biotin-labeled sHLA molecule in combination with a fluorescently labeled streptavidin conjugate of choice can be analyzed by flow cytometry or sorted according to their antigenic type.

Resources

SOLUBLE HLA TECHNOLOGY

Learn more about our sHLA Technology and how it can improve the quality and speed of your science

HLA APPLICATIONS

Explore the landscape of HLA applications in the fields of transplantation, autoimmunity, cancer and infectious diseases and find new ways to improve your research

SOLUBLE HLA PUBLICATIONS

Read more about our publications and discover new resources and ideas to support your endeavors

Frequently Asked Questions

How does a sHLA Class I molecule look like?

Structurally, sHLA Class I proteins consist of a heavy chain, a light chain (b2m) and the peptide they present forming a trimeric complex. Various sHLA alleles have an added purification tag (VLDL) at the carboxy end of the α3 domain.

What is the molecular weight of a sHLA Class I molecule?

Soluble HLA Class I glycosylated protein complexes are 47 kDa in size consisting of a 33 kDa heavy chain, an 11 kDa beta-2-microglobulin light chain and a small size peptide (8 to 11mer) in the groove.

Can I freeze sHLA molecules?

We do not recommend freezing sHLA molecules as loss of activity up to 20% can occur during a freeze-thaw cycle.

Browse All FAQS

Related Products & Services

HLA-A Proteins

Choose from more than 35 HLA-A alleles to detect, profile, or monitor antigen-specific immune responses from antibodies to immune cell populations

HLA-C Proteins

Discover a selection of over 20 HLA-C alleles, the dominant ligand for KIR on NK cells for your immunological research

Peptide Validation and Screening Services

Competition-based HLA peptide binding assays for the validation and screening of putative T cell epitopes