My Cart
Search
Advanced Search
Popular Searches
hla (419)
Hla C (419)
Hla C 06 (419)
hla test (419)
Recent Searches
DQ (44)
hla (419)
HLA–B*13:01 (2)
HLA–B*13 (4)
Menu
Back to Home

HLA-DQ

From the re-emerging role of HLA-DQ in transplantation medicine to the growing attention in autoimmune conditions and disease susceptibility

We provide a matrix of highly representative HLA-DQ alleles that help to drive novel research to prevent transplant rejection and to contribute to more insight into CD4+ T cell responses. Learn more about HLA.

BROWSE ALL sHLA-DQ ALLELES
Popular Products
HLA–DQB1*02:01/DQA1*02:01
Most popular high-frequency allele and linked to celiac disease
HLA–DQB1*03:01/DQA1*05:03
Very high frequency allele and popular in serological studies
HLA–DQB1*03:02/DQA1*02:01
Commonly linked to autoimmune diseases in the human population
HLA–DQB1*06:02/DQA1*01:02
Common allele and described as being strongly associated with narcolepsy
HLA–DQB1*04:02/DQA1*04:01
Among the top DQ alleles found in the human population
HLA–DQB1*05:02/DQA1*01:01
Common allele with reported association to Myasthenia Gravis
HLA–DQB1*05:01/DQA1*01:01
Frequent allele appearing to be associated with analgesic intolerance
Map of available HLA-DQ alleles
EXPAND HLA-DQ MAP

HLA-DQ Allele Map

Download our list of HLA-DQ alleles to view all available sHLA proteins as well as products in development.

Download HLA-DQ Alleles

Featured Assays

null

General ImmunoAssays

Soluble HLA are extremely well suited as antigens in solid phase immunoassays for the detection and characterization of HLA-specific antibodies. Because of their antigenic integrity, they provide increased accuracy and specificity.
null

Bead-based ImmunoAssays

Biotin-labeled sHLA molecules are easily immobilized on any streptavidin-coated bead in immunoassays to measure antibody analytes. Fluorescent imaging is used to measure the amount of captured antibody.
null

Cell-Based ImmunoAssays

Biotin-labeled sHLA proteins coupled with a fluorescently labeled streptavidin conjugate are very sensitive detectors in ELISpot assays to profile the antibody specificities of i.e. HLA-specific B cells.
null

Flow Cytometry/Cell Sorting

Immune cells stained with a biotin-labeled sHLA molecule in combination with a fluorescently labeled streptavidin conjugate of choice can be analyzed by flow cytometry or sorted according to their antigenic type.

Resources

SOLUBLE HLA TECHNOLOGY

Learn more about our sHLA Technology and how it can improve the quality and speed of your science

HLA APPLICATIONS

Explore the landscape of HLA applications in the fields of transplantation, autoimmunity, cancer and infectious diseases and find new ways to improve your research

SOLUBLE HLA PUBLICATIONS

Read more about our publications and discover new resources and ideas to support your endeavors

Frequently Asked Questions

What is the molecular weight of a sHLA Class II molecule?

Soluble HLA Class II glycosylated protein complexes are 61 kDa in size consisting of a 27 kDa beta chain and a 26 kDa alpha chain with a small size peptide (15 to 24mer) in the groove.

What is a DQ matrix?

Because of the high polymorphism associated with DQ molecules, we have formulated a combinatorial matrix consisting of a selection of alpha (DQA1) and beta (DQB1) chains. The DQ matrix consists of 13 DQA molecules that pair with 17 DQB molecules resulting in a combinatorial matrix of 221 possible combinations.

What does a sHLA Class II molecule look like?

Structurally, sHLA Class II proteins are heterodimeric glycoproteins consisting of an alpha chain, a beta chain and an endogenously loaded peptide they present forming a trimeric complex.

Browse All FAQS

Related Products & Services

HLA-B Proteins

Select from a pool of over 65 HLA-B alleles to drive your immunological research to identify antibody immune responses or visualize antigen-specific immune cells

HLA-C Proteins

Discover a selection of over 20 HLA-C alleles, the dominant ligand for KIR on NK cells for your immunological research

Peptide Validation and Screening Services

Competition-based HLA peptide binding assays for the validation and screening of putative T cell epitopes